Blar i forfatter "Janice, Jessin"

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    • Alternative vanHAX promoters and increased vanA-plasmid copy number resurrect silenced glycopeptide resistance in Enterococcus faecium 

      Wagner, Theresa; Janice, Jessin; Sivertsen, Audun; Sjögren, Ingegerd; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-26)
      <i>Background</i> - Vancomycin variable enterococci (VVE) are <i>van</i>-positive isolates with a susceptible phenotype that can convert to a resistant phenotype during vancomycin selection.<p> <p><i>Objectives</i> - To describe a vancomycin-susceptible <i>vanA</i>-PCR positive ST203 VVE <i>Enterococcus faecium</i> isolate (VVE<i>Swe</i>-S) from a liver transplantation patient in Sweden which ...

    • Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant pseudomonas aeruginosa 

      Janice, Jessin; Agyepong, Nicholas; Owusu-Ofori, Alex; Govinden, Usha; Essack, Sabiha; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Pedersen, Torunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-17)
      Two novel bla<sub>DIM-1</sub>- or bla<SUB>IMP-1</SUB>-containing genomic islands (GIs) were discovered by whole-genome sequence analyses in four extensively drug-resistant (XDR) <i>Pseudomonas aeruginosa</i> isolates from inpatients at a tertiary hospital in Ghana. The strains were of sequence type 234 (ST234) and formed a phylogenetic clade together with ST111, which is recognized as a global ...

    • Comparative Genomics Reveals Factors Associated with Phenotypic Expression of Wolbachia 

      Baião, GC; Janice, Jessin; Galinou, M; Klasson, Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)
      Wolbachia is a widespread, vertically transmitted bacterial endosymbiont known for manipulating arthropod reproduction. Its most common form of reproductive manipulation is cytoplasmic incompatibility (CI), observed when a modification in the male sperm leads to embryonic lethality unless a compatible rescue factor is present in the female egg. CI attracts scientific attention due to its implications ...

    • Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients Involving Six Different Hospitals in Denmark. 

      Samuelsen, Ørjan; Hansen, Frank; Aasnæs, Bettina; Hasman, Henrik; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Lilje, Berit; Janice, Jessin; Jakobsen, Lotte; Littauer, Pia; Søes, Lillian M; Holzknecht, Barbara J.; Andersen, Leif P; Stegger, Marc; Andersen, Paal S.; Hammerum, Anette M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-23)
      The diversity of OXA-48-like carbapenemases are continually expanding. In this study, we describe the dissemination and characteristics of a novel class D carbapenemase (CHDL) named OXA-436. In total, six OXA-436-producing Enterobacteriaceae isolates including Enterobacter asburiae (n=3), Citrobacter freundii (n=2) and Klebsiella pneumoniae (n=1) were identified in four patients in the period between ...

    • Emergence of vancomycin-resistant enterococci from vancomycin susceptible enterococci in hospitalized patients under antimicrobial therapy 

      Janice, Jessin; Wagner, Theresa Maria; Olsen, Karina; Hegstad, Joachim; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-19)
      Objectives: Enterococci are opportunistic pathogens with plastic genomes that evolve, acquire, and transmit antimicrobial-resistant determinants such as vancomycin resistance clusters. While vancomycinresistant enterococci (VRE) have emerged as successful nosocomial pathogens, the mechanism by which vancomycin-susceptible enterococci (VSE) transform to VRE in hospitalized patients remains ...

    • The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics 

      al Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen; Löhr, Iren Høyland; Sundsfjord, Arnfinn Ståle; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)
      Objectives - We aimed to characterize the vanE cluster and its genetic support in the first Norwegian vanE-type isolates and assess genetic relatedness to other vanE isolates.<p> <p>Methods - Two vanE-type vancomycin resistant Enterococcus faecalis (vanE-VREfs) isolates (E1 and E2) recovered from the same patient 30 months apart were examined for antimicrobial susceptibility, genome sequence, ...

    • Genomic characterization of multidrug-resistant ESBL-producing Klebsiella pneumoniae isolated from a Ghanaian teaching hospital 

      Agyepong, Nicholas; Govinden, Usha; Owusu-Ofori, Alex; Amoako, Daniel Gyamfi; Allam, Mushal; Janice, Jessin; Pedersen, Torunn Annie; Sundsfjord, Arnfinn; Essack, Sabiha (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)
      <p><i>Objectives - </i>This study delineated the clonal lineages, antibiotic resistome and plasmid replicon types in multidrug-resistant <i>K. pneumoniae</i> isolates from a teaching hospital in Ghana. <p><i>Methods - </i>Identification and antibiotic susceptibility testing were done using the MALDI-TOF MS and Vitek-2 automated system. Genomic DNA extraction was carried out using the NucliSens ...

    • Genomic insights into Enterococcus faecium isolates from marine bivalves highlight One Health concerns and healthcare linkages 

      von Barner Tvedegaard Heim, Amalie; Janice, Jessin; Bjørnholt, Jørgen; Lunestad, Bjørn Tore; Hegstad, Kristin; Svanevik, Cecilie Smith (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-12)
      Enterococci, especially Enterococcus faecium, are one of today’s leading causes of multidrug-resistant infections in hospital settings. The marine environment may harbour enterococci, but its role as an evolutionary niche and as a vector for the spread of enterococci is sparsely investigated. Hence, by applying enterococci in bivalves as a sentinel tool, this study aimed to describe the prevalence ...

    • Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania 

      Pedersen, Torunn Annie; Tellevik, Marit Gjerde; Kommedal, Øyvind; Lindemann, Paul Christoffer; Moyo, Sabrina John; Janice, Jessin; Blomberg, Bjørn; Samuelsen, Ørjan; Langeland, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
      Increased knowledge about the role of horizontal gene transfer is key to improve our understanding of the spread of antimicrobial resistance (AMR) in human populations. We therefore studied the dissemination of the <i>bla</i><sub>CTX-M-15</sub> extended-spectrum-β-lactamase (ESBL) gene in <i>Klebsiella pneumoniae</i> isolates obtained from stool samples from hospitalized children and healthy controls ...

    • Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020 

      Lindemann, Paul Christoffer; Pedersen, Torunn Annie; Oma, Dorthea Hagen; Janice, Jessin; Grøvan, Fredrik; Chedid, Ghantous Milad; Hafne, Liv Jorunn; Josefsen, Ellen Haldis; Kacelnik, Oliver; Sundsfjord, Arnfinn; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      Infections with OXA-244-carbapenemase-producing Escherichia coli with sequence type (ST)38 have recently increased in Europe. Due to its low-level activity against carbapenems, OXA-244 can be difficult to detect. Previous assessments have not revealed a clear source and route of transmission for OXA-244-producing E. coli, but there are indications of non-healthcare related sources and community ...

    • Molecular Epidemiological Characterisation of ESBL- and Plasmid-Mediated AmpC-Producing Escherichia coli and Klebsiella pneumoniae at Kamuzu Central Hospital, Lilongwe, Malawi 

      Choonara, Faheema Ebrahim; Haldorsen, Bjørg; Janice, Jessin; Mbanga, Joshua; Ndhlovu, Isaac; Saulosi, Osborne; Maida, Tarsizio; Lampiao, Fanuel; Simonsen, Gunnar Skov; Essack, Sabiha Yusuf; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-14)
      The global rise in infections caused by multidrug resistant (MDR) Enterobacterales poses a public health problem. We have performed a molecular epidemiological characterisation of representative plasmid-mediated AmpC (pAmpC) and ESBL-positive clinical isolates of Escherichia coli (n = 38) and Klebsiella pneumoniae (n = 17) from a tertiary hospital in Malawi collected in 2017. BlaCTX-M-15 was the ...

    • Nationwide, population-based observational study of the molecular epidemiology and temporal trend of carbapenemase-producing Enterobacterales in Norway, 2015 to 2021 

      Ljungquist, Oskar; Haldorsen, Bjørg; Pöntinen, Anna Kaarina; Janice, Jessin; Josefsen, Ellen Haldis; Elstrøm, Petter; Kacelnik, Oliver; Sundsfjord, Arnfinn; Samuelsen, Ørjan; Handal, Nina; Ranheim, Trond Egil; Hansen, Bent-Are; Mjøen, Andreas Fossum; Lindemann, Paul Christoffer; Nilsen, Einar; Zaragkoulias, Kyriakos; Larsen, Hege Elisabeth; Bjørnholt, Jørgen; Gammelsrud, Karianne Wiger; Jakovljev, Aleksandra; Löhr, Iren Høyland; Bredberg, Anders; Marvik, Åshild; Minge, Christina; Tofteland, Ståle; Papp, Kristina; Onken, Annette; Weme, Einar Tollaksen; Guennigsman, Brian Albert (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      National and regional carbapenemaseproducing Enterobacterales (CPE) surveillance is essential to understand the burden of antimicrobial resistance, elucidate outbreaks, and develop infection-control or antimicrobial-treatment recommendations. Aim: This study aimed to describe CPE and their epidemiology in Norway from 2015 to 2021. Methods: A nationwide, population-based observational study of ...

    • Novel genomic islands and a new vanDsubtype in the first sporadic VanD-type vancomycin resistant enterococci in Norway 

      AL-Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen Vildershøj; Jakovljev, Aleksandra; Hultström, Maria Elisabeth; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)
      Background - Vancomycin-resistant enterococci (VRE) represent several types of transferable vancomycin resistance gene clusters. The vanD type, associated with moderate to high level vancomycin resistance, has only sporadically been described in clinical isolates. The aim of this study was to perform a genetic characterization of the first VanD-type VRE strains detected in Norway.<p> <p>Methods ...

    • The population structure of vancomycin-resistant and -susceptible Enterococcus faecium in a low-prevalence antimicrobial resistance setting is highly influenced by circulating global hospital-associated clones 

      al Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen; Kacelnik, Oliver; Haldorsen, Bjørg C; Nygaard, Randi Monsen; Hegstad, Joachim; Sundsfjord, Arnfinn Ståle; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-19)
      Between 2010 and 2015 the incidence of vancomycin-resistant Enterococcus faecium (VREfm) in Norway increased dramatically. Hence, we selected (1) a random subset of vancomycin-resistant enterococci (VRE) from the Norwegian Surveillance System for Communicable Diseases (2010–15; n=239) and (2) Norwegian vancomycin-susceptible E. faecium (VSEfm) bacteraemia isolates from the national surveillance ...

    • Reversible vancomycin susceptibility within emerging ST1421 Enterococcus faecium strains is associated with rearranged vanA-gene clusters and increased vanA plasmid copy number 

      Wagner, Theresa; Janice, Jessin; Schluz, Marc; Ballard, Susan; da Silva, Anders; Coombs, Geoffrey W; Daley, Denise; Pang, Stanley; Mowlaboccus, Shakeel; Stinear, Tim; Hegstad, Kristin; Howden, Benjamin P; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)
      Vancomycin variable enterococci (VVE) are van-positive enterococci with a vancomycin-susceptible phenotype (VVE-S) that can convert to a resistant phenotype (VVE-R) and be selected for during vancomycin exposure. VVE-R outbreaks have been reported in Canada and Scandinavian countries. The aim of this study was to examine the presence of VVE in whole genome sequenced (WGS) Australian bacteremia ...

    • Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae 

      Hegstad, Kristin; Mylvaganam, Haima; Janice, Jessin; Josefsen, Ellen H.; Sivertsen, Audun; Skaare, Dagfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-29)
      <i>Haemophilus influenzae</i> colonizes the respiratory tract in humans and causes both invasive and noninvasive infections. Resistance to extended-spectrum cephalosporins in <i>H. influenzae</i> is rare in Europe. In this study, we defined acquired resistance gene loci and <i>ftsI</i> mutations in multidrug-resistant (MDR) and/or PBP3-mediated beta-lactam-resistant (rPBP3) <i>H. influenzae</i> ...